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KMID : 0376219830200030631
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Chonnam Medical Journal
1983 Volume.20 No. 3 p.631 ~ p.634
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A Dynamic Experimental Model Simulating Serum Antibiotic Concentration
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Cho Soon-Heum
Chung Sun-Sik
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Abstract
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In order to study the bactericidal effect of antibiotics in a system approaching actual therapy, a dynamic model which simulates concentration variation was developed. This was done using a intermediary dialysis. Three aminoglycosides(amikacin, gentamicin, tobramycin) were used in a system resembling the serum rates of the normal individual. The apparatus is fairly accurate, the variation coefficients being of the order of 10 to 14%. This model enables the simulation of numerous therapeutic situations. It is, however, limited to only dialyzable antibiotics.
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KEYWORD
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